diff --git a/gnupg/_meta.py b/gnupg/_meta.py
index 934eba8..f93bae4 100644
--- a/gnupg/_meta.py
+++ b/gnupg/_meta.py
@@ -537,8 +537,8 @@ class GPGBase(object):
 
         if passphrase: cmd.append('--batch --passphrase-fd 0')
 
-        if self.use_agent: cmd.append('--use-agent')
-        else: cmd.append('--no-use-agent')
+        if self.use_agent is True: cmd.append('--use-agent')
+        elif self.use_agent is False: cmd.append('--no-use-agent')
 
         # The arguments for debugging and verbosity should be placed into the
         # cmd list before the options/args in order to resolve Issue #76:
diff --git a/gnupg/gnupg.py b/gnupg/gnupg.py
index 6a2fb46..12b46ce 100644
--- a/gnupg/gnupg.py
+++ b/gnupg/gnupg.py
@@ -161,6 +161,12 @@ class GPG(GPGBase):
         # fatal error (at least it does with GnuPG>=2.0.0):
         self.create_trustdb()
 
+        # The --no-use-agent and --use-agent options were deprecated in GnuPG
+        # 2.x, so we should set use_agent to None here to avoid having
+        # GPGBase._make_args() add either one.
+        if self.is_gpg2():
+            self.use_agent = None
+
     @functools.wraps(_trust._create_trustdb)
     def create_trustdb(self):
         if self.is_gpg2():