diff --git a/wrapper/rust/wolfssl-wolfcrypt/build.rs b/wrapper/rust/wolfssl-wolfcrypt/build.rs
index 5feec53959..76a043fca0 100644
--- a/wrapper/rust/wolfssl-wolfcrypt/build.rs
+++ b/wrapper/rust/wolfssl-wolfcrypt/build.rs
@@ -38,39 +38,61 @@ fn wolfssl_repo_lib_dir() -> Result<String> {
     Ok(format!("{}/src/.libs", wolfssl_repo_base_dir()?))
 }
 
-/// Returns the validated `WOLFSSL_PREFIX` installation prefix, if usable.
+/// Directories located under a validated `WOLFSSL_PREFIX` installation.
+struct WolfsslPrefixDirs {
+    include: String,
+    lib: String,
+}
+
+/// Returns the directories of the `WOLFSSL_PREFIX` installation, if usable.
 ///
 /// A prefix is only accepted if it provides both halves of an installation:
-/// a `lib` directory and an `include/wolfssl` directory.  A prefix holding
-/// only one of them is rejected outright, so that the headers and the library
-/// we build against always come from the same place.
+/// a library directory (`lib` or `lib64`) and an `include/wolfssl` directory.
+/// A prefix holding only one of them is rejected outright, so that the headers
+/// and the library we build against always come from the same place.
 ///
 /// The result is computed once and cached, so any warning is printed once.
-fn wolfssl_prefix() -> Option<&'static str> {
-    static PREFIX: OnceLock<Option<String>> = OnceLock::new();
-    PREFIX.get_or_init(compute_wolfssl_prefix).as_deref()
+fn wolfssl_prefix_dirs() -> Option<&'static WolfsslPrefixDirs> {
+    static DIRS: OnceLock<Option<WolfsslPrefixDirs>> = OnceLock::new();
+    DIRS.get_or_init(compute_wolfssl_prefix_dirs).as_ref()
 }
 
 /// Read `WOLFSSL_PREFIX` from the environment and validate its layout.
 ///
-/// Returns `None` (after warning) if the variable is unset, malformed, or
-/// does not point at a directory containing both `lib` and `include/wolfssl`.
-fn compute_wolfssl_prefix() -> Option<String> {
+/// Returns `None` (after warning) if the variable is unset, malformed, or does
+/// not point at a directory containing both `include/wolfssl` and a library
+/// directory.
+fn compute_wolfssl_prefix_dirs() -> Option<WolfsslPrefixDirs> {
     let prefix = env::var("WOLFSSL_PREFIX").ok()?;
     if prefix.is_empty() || prefix.contains('\n') {
         println!("cargo:warning=ignoring WOLFSSL_PREFIX");
         return None;
     }
     let prefix_path = Path::new(&prefix);
-    for subdir in [prefix_path.join("lib"),
-                   prefix_path.join("include").join("wolfssl")] {
-        if !subdir.is_dir() {
-            println!("cargo:warning=ignoring WOLFSSL_PREFIX: {} is not a directory",
-                     subdir.display());
-            return None;
-        }
+
+    let include_dir = prefix_path.join("include");
+    if !include_dir.join("wolfssl").is_dir() {
+        println!("cargo:warning=ignoring WOLFSSL_PREFIX: {} is not a directory",
+                 include_dir.join("wolfssl").display());
+        return None;
     }
-    Some(prefix)
+
+    // Installations are found under either lib/ or lib64/ depending on the
+    // platform and how wolfSSL was configured.
+    let lib_names = ["lib", "lib64"];
+    let Some(lib_dir) = lib_names.iter()
+                                 .map(|name| prefix_path.join(name))
+                                 .find(|dir| dir.is_dir()) else {
+        println!("cargo:warning=ignoring WOLFSSL_PREFIX: none of {} are directories",
+                 lib_names.map(|name| prefix_path.join(name).display().to_string())
+                          .join(", "));
+        return None;
+    };
+
+    Some(WolfsslPrefixDirs {
+        include: include_dir.display().to_string(),
+        lib: lib_dir.display().to_string(),
+    })
 }
 
 /// Returns the include directory for wolfssl headers.
@@ -78,8 +100,8 @@ fn compute_wolfssl_prefix() -> Option<String> {
 /// If `WOLFSSL_PREFIX` is usable, returns `{WOLFSSL_PREFIX}/include`.
 /// Otherwise falls back to the repo root if it exists (for in-tree host builds).
 fn wolfssl_include_dir() -> Result<Option<String>> {
-    if let Some(prefix) = wolfssl_prefix() {
-        Ok(Some(format!("{}/include", prefix)))
+    if let Some(dirs) = wolfssl_prefix_dirs() {
+        Ok(Some(dirs.include.clone()))
     } else {
         let base = wolfssl_repo_base_dir()?;
         let base_path = Path::new(&base);
@@ -96,11 +118,12 @@ fn wolfssl_include_dir() -> Result<Option<String>> {
 
 /// Returns the library directory for libwolfssl.
 ///
-/// If `WOLFSSL_PREFIX` is usable, returns `{WOLFSSL_PREFIX}/lib`.
+/// If `WOLFSSL_PREFIX` is usable, returns `{WOLFSSL_PREFIX}/lib` or
+/// `{WOLFSSL_PREFIX}/lib64`, whichever exists.
 /// Otherwise falls back to the in-tree build output directory if it exists.
 fn wolfssl_lib_dir() -> Result<Option<String>> {
-    if let Some(prefix) = wolfssl_prefix() {
-        Ok(Some(format!("{}/lib", prefix)))
+    if let Some(dirs) = wolfssl_prefix_dirs() {
+        Ok(Some(dirs.lib.clone()))
     } else {
         let repo_lib_dir = wolfssl_repo_lib_dir()?;
         if Path::new(&repo_lib_dir).exists() {